The 9" ford will not bolt right in, but basically everything else is your choice as to what you want to drive. Consider daily driver, race, or a good mix of both. Big non-roller cams equal low vaccuum and loss of accessories including brakes, automatic trans shifting, and since Blazers have a vaccuum operated system for the vent and floor switches, it could create a problem there unless you go with a vaccuum reserve canister or pump.
Basically, the answer is, Speed costs money, how fast do you want to go??